On October 6th local time, the Karolinska Institute in Sweden announced that the 2025 Nobel Prize in Physiology or Medicine was awarded to scientists Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their research contributions in peripheral immune tolerance. The laureates will share the prize money of 11 million Swedish kronor (approximately 8.32 million yuan).
The laureates discovered the "bodyguards" of the immune system - regulatory T cells, thereby laying the foundation for a new field of research.
Mary E. Bronko was born in 1961 and received her Ph.D. in Molecular Biology from Princeton University in 1991. Her research focuses on the intersection of biomedicine, immunology, and systems biology.
Fred Ramsdell, born in 1960, is not only active in the field of basic research but also promotes the development of immune-related therapies in the biotechnology industry, dedicated to transforming fundamental immunological discoveries into intervention strategies that can be used to treat autoimmune diseases, cancer, or for immune regulation.
Shiwen Sakaguchi, born in 1951, is a professor at the Frontier Research Center for Immunology at Osaka University in Japan. His pioneering work in the field of immune regulation has earned him numerous international and domestic awards in Japan.